Anxiety
A New Generation of Cold Water Dispersible and Soluble Ingredients
Anxiety is a normal and often helpful emotion that we experience in response to stress or perceived danger. It can manifest as feelings of apprehension, uneasiness, nervousness, and worry, restlessness, fatigue, difficulty concentrating, irritability, muscle tension, and sleep disturbances. In small doses, anxiety can help us to stay alert and focused! But when it becomes excessive or persistent, it can be detrimental to our mental and physical health.
Anxiety disorders are a group of mental health conditions that involve excessive and chronic feelings of anxiety that interfere with daily life. Treatment for anxiety disorders can include medication, therapy, lifestyle changes, such as exercise and stress management techniques, as well as supplementation. With proper treatment, many people with anxiety and anxiety disorders can alleviate their symptoms and improve their quality of life.
LEO-HB® Ingredients for Anxiety
Anandamide LEO-HB®
Caryophyllene LEO-HB®
CBD LEO-HB®
O.E.A. LEO-HB®
P.E.A LEO-HB®
Anandamide works by binding to and activating CB1 receptors in the brain, which are part of the endocannabinoid system. This system plays a key role in regulating mood, stress, and anxiety levels in the body. When anandamide binds to CB1 receptors, it can help to reduce anxiety and promote a sense of calm and relaxation. Anandamide has been shown to have anxiolytic effects in animal studies. Human studies have suggested that the endocannabinoid system may play a role in anxiety disorders. One study found that individuals with anxiety disorders had lower levels of anandamide in their cerebrospinal fluid than healthy controls.*
Caryophyllene has been found to bind selectively to the CB2 receptor, which is primarily found in immune cells but also has a presence in the brain. This interaction with CB2 receptors may help to reduce inflammation and pain, which are often associated with anxiety. In addition, caryophyllene has been shown to have anxiolytic effects in animal studies. For example, a 2017 study published in the journal Neuropharmacology found that caryophyllene oxide, a derivative of caryophyllene, reduced anxiety-like behaviors in mice by interacting with the endocannabinoid and TRPV1 (vanilloid) receptors located in the ventral medial prefrontal cortex (vmPFC).*
CBD works by interacting with the body’s endocannabinoid system, which plays a key role in regulating mood, stress, and anxiety levels in the body. It has been shown to interact with a variety of receptors, including CB1 and CB2 receptors. CBD has been shown to increase the production of anandamide, a neurotransmitter that has been linked to feelings of calm and relaxation. CBD may also help to reduce anxiety by modulating the activity of the serotonin and GABA neurotransmitter systems, both of which are involved in regulating mood and anxiety levels. CBD has also been shown to have anti-inflammatory and antioxidant properties. Chronic inflammation and oxidative stress have been linked to anxiety and other mental health disorders, so these properties may also play a role in CBD’s ability to alleviate anxiety.*
Research has suggested that OEA can activate certain receptors in the brain that are involved in regulating anxiety, such as the peroxisome proliferator-activated receptor alpha (PPAR-α) and the transient receptor potential vanilloid type-1 (TRPV1) receptor. By activating these receptors, OEA may help to reduce feelings of anxiety and promote a sense of calmness. Additionally, OEA has been shown to have anti-inflammatory effects, which may also contribute to its ability to reduce anxiety. Chronic inflammation has been linked to the development of anxiety and other mood disorders, so reducing inflammation may help to improve overall mental health.*
Research has suggested that PEA can activate certain receptors in the brain that are involved in regulating anxiety, such as the peroxisome proliferator-activated receptor alpha (PPAR-α) and the transient receptor potential vanilloid type-1 (TRPV1) receptor. By activating these receptors, PEA may help to reduce feelings of anxiety and promote a sense of calmness. Additionally, PEA has been shown to have anti-inflammatory effects, which may also contribute to its ability to reduce anxiety. Chronic inflammation has been linked to the development of anxiety and other mood disorders, so reducing inflammation may help to improve overall mental health.*