• Balances/ Uplifts Mood*
  • Stress*
  • Relaxation, Calmness*
  • Sleep*
  • Pain Management*
Relax with Caryophyllene LEO-HB®

A New Generation of Cold Water Dispersible and Soluble Ingredients


  • Off-white/Ivory free-flowing powder with a mild, floral taste,  derived from clove buds
  • Instantly Cold Water Dispersible
  • Caryophyllene is characterized as both a terpene and a cannabinoid. It has been extensively studied for its pain killing and anti-inflammatory benefits, for aiding with anxiety and depression.

Vegan and Non-Vegan Formulas Available

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Clean Label Ingredients

Active Ingredient:
Syzygium aromaticum

Other Ingredients:
Non-Vegan Formula: Hydrolyzed collagen and Sunflower Lecithin
Vegan Formula: Plant Protein Hydrolysate and Sunflower Lecithin

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Caryophyllene in Clinical Studies

Caryophyllene is a natural bicyclic sesquiterpene that is found in many plants and spices, including black pepper, cloves, and cannabis. It is known for its distinctive spicy, woody, and peppery aroma. Caryophyllene has been the subject of much research due to its potential health benefits, including its anti-inflammatory and antioxidant properties. It is believed to have a role in pain relief, anxiety reduction, and may also have neuroprotective and anti-cancer effects.

In addition, caryophyllene has been found to interact with the endocannabinoid system in the body, which is responsible for regulating a range of physiological processes, including pain sensation, mood, and appetite. As a result, it has gained attention as a potential therapeutic agent for a variety of conditions.

  1. Anti-inflammatory effects: Caryophyllene has been found to have potent anti-inflammatory effects, which may be useful in treating inflammatory conditions such as arthritis, inflammatory bowel disease, and other chronic inflammatory conditions.*
  2. Pain relief: Caryophyllene has been found to have analgesic (pain-relieving) properties. It may be useful in treating chronic pain conditions, such as neuropathic pain, and may also have potential as an alternative to opioid pain medications.*
  3. Anxiety reduction: Caryophyllene has been found to have anxiolytic (anxiety-reducing) effects, which may be helpful in treating anxiety disorders and promoting relaxation.*
  4. Neuroprotective effects: Some research suggests that caryophyllene may have neuroprotective effects, which may help protect the brain from damage and reduce the risk of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.*
  5. Anti-cancer effects: Some studies have shown that caryophyllene may have anti-cancer effects, particularly in inhibiting the growth and spread of cancer cells in the breast, colon, and prostate.*

LEO-HB® Technology

  • LEO-HB® is an eco-friendly, state-of-the-art, solid-solid technology that turns poorly soluble, bioactive ingredients with low bioavailability into free-flowing high performance powders that are instantly Cold Water Dispersible and/or Soluble with maximized bioavailability.
  • Contrary to many other technologies, LEO-HB® is a 100% natural, clean-label process, only uses food-grade Non-GMO ingredients, NO solvents (NO P.E.G, NO Polysorbates) and has no negative impact on the digestive tract.
  • Only Food-Grade, Non-GMO, Clean Label ingredients are used for every LEO-HB® ingredient:  natural carrier (vegan or non-vegan), selected bioactive extract, natural glycerin (NO artificial emulsifiers, NO excipients, NO solvents)
  • Final LEO-HB® ingredient powders:
    • Are Cold Water Dispersible (80% min. vs. 0% for the unprocessed raw material)
    • Offer maximum bioavailability from 3x to 20x+
    • Offer customizable particle size

Design Your Next Cutting-Edge Product with LEO-HB®

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