Deep Breaths on Beach: Andrographis LEO-HB® helps the Respiratory system

The Health Benefits and Uses of Andrographis: Insights from Human Trials

Abstract: Andrographis paniculata, commonly known as Andrographis, is a medicinal herb with a long history of traditional use in various parts of the world. This essay explores the health benefits and uses of Andrographis, with a specific focus on its effectiveness as demonstrated through human trials. It delves into the plant’s phytochemistry, historical uses, and its applications in modern medicine, while also discussing the findings and conclusions of human trials to better understand its therapeutic potential.


  • Introduction

  • Phytochemistry

  • Historical Uses

  • Modern Uses

  • Human Trials

  • Improvement of  Bioavailability using LEO-HB® technology

  • Conclusion


Andrographis paniculata, or  Andrographis as it is commonly called, is a plant with a rich history of use in traditional medicine across Asia, particularly in countries like India, China, and Thailand. In recent years, it has gained attention in the field of modern medicine for its potential health benefits and therapeutic properties. This essay aims to explore the health benefits and uses of Andrographis, focusing on human trials to assess its effectiveness in various application

Phytochemistry of Andrographis:

Andrographis paniculata contains a wide array of phytochemical compounds that contribute to its medicinal properties. The primary bioactive constituents in Andrographis are andrographolides, which have been extensively studied for their potential health benefits. Andrographolides possess anti-inflammatory, immunomodulatory, and antioxidant properties, making Andrographis a promising source of natural medicine.

Historical Uses:

Andrographis has a long history of traditional use in different parts of Asia. In Ayurvedic medicine, it is known as “Kalmegh” and has been used for centuries to treat various ailments. Traditional uses of Andrographis include:

  1. Immune Support: Andrographis has been used traditionally to boost the immune system, especially during the cold and flu season.
  2. Fever and Infections: It has been employed to reduce fever and treat infections, including upper respiratory tract infections.
  3. Digestive Disorders: Andrographis has been used to alleviate digestive issues such as dysentery.
  4. Anti-Inflammatory Agent: In traditional medicine, it is believed to have anti-inflammatory properties, making it useful for conditions such as arthritis.
Closeup dry Andrographis paniculata leaf powder in wooden bowl and fresh paniculata leaves isolated on white background

Modern Uses:

In modern medicine, Andrographis has gained recognition for its potential therapeutic applications. Some of its uses include:

  1. Immune Support** Andrographis is often used as an immune booster, particularly during the cold and flu season. Several over-the-counter supplements containing Andrographis are marketed for this purpose.
  2. Upper Respiratory Tract Infections** Some studies suggest that Andrographis may help reduce the severity and duration of upper respiratory tract infections, such as the common cold.
  3. Anti-Inflammatory Properties** The anti-inflammatory properties of andrographolides have led to investigations into their potential use in managing chronic inflammatory conditions.
  4. Digestive Health** Andrographis has been explored as a natural remedy for digestive disorders, including diarrhea and irritable bowel syndrome.
  5. Antioxidant Effects** Its antioxidant properties are of interest in the context of reducing oxidative stress and its associated health issues.

Human Trials on Andrographis:

To understand the effectiveness of Andrographis in modern medicine, numerous human trials have been conducted. These trials have provided valuable insights into its potential health benefits. Here are some key conclusions from human trials on Andrographis:

  1. Upper Respiratory Tract Infections: Andrographis has been extensively studied for Respiratory Health.  One such example, a  double-blind, placebo-controlled study published in the Journal of Clinical and Diagnostic Research in 2017* assessed the use of Andrographis paniculata extract in individuals with upper respiratory tract infections. The study found that Andrographis extract significantly reduced the duration and severity of symptoms compared to the placebo group. This suggests that Andrographis can be an effective remedy for common colds and similar infections.
  2. Immune Function: A study published in the Indian Journal of Pharmacology in 2012* investigated the immunomodulatory effects of Andrographis paniculata. The results suggested that Andrographis supplementation could enhance immune function, making it a potential choice for immune support.
  3. Anti-Inflammatory Effects: Andrographis has been studied for its anti-inflammatory properties in various conditions, including osteoarthritis. A randomized, double-blind, placebo-controlled trial published in the Journal of Evidence-Based Integrative Medicine in 2019* found that Andrographis extract reduced pain and improved joint function in osteoarthritis patients, indicating its potential as an anti-inflammatory agent. Another study published in Phytomedicine in 2023 Identified Andrographolide as a novel FABP4 inhibitor for osteoarthritis treatment.* It’s Conclusion: Our results indicate that the inhibition of FABP4 activity by AP explains the anti-OA properties of Andrographis paniculata by protecting against cartilage degradation in OA patients. Additionally, our findings suggest that AP may be a promising therapeutic agent for OA treatment due to its ability to alleviate cartilage damage and bone erosion.
  4. Digestive Health: The effects of Andrographis on digestive health have been explored in clinical trials. A study published in the Journal of Clinical Gastroenterology in 2015* investigated the use of Andrographis extract in patients with irritable bowel syndrome (IBS). The results showed a significant reduction in IBS symptoms, suggesting its potential as a natural remedy for digestive disorders.

  5. Antioxidant Properties: Andrographis has also been studied for its antioxidant effects. An article published in the journal “Food and Chemical Toxicology” in 2018* highlighted its ability to reduce oxidative stress and protect cells from damage caused by free radicals.

The LEO-HB® Technology Advantage

  • LEO-HB® is an eco-friendly, state-of-the-art solid-solid  technology that turns poorly soluble, bioactive ingredients with low bioavailability into free-flowing high performance powders, that are instantly Cold Water Dispersible and/or Soluble.
  • Contrary to many other technologies, LEO-HB® is a 100% natural, clean label process, only uses food-grade,  non-GMO ingredients, and NO solvents, (NO P.E.G, NO Polysorbates, NO artificial emulsifiers) and has no negative impact on the digestive tract.
  • Our Solid-Solid dispersion technology allows the enhancement of bio-accessibility & solubility of Andrographolide (see figures below – based on 60 mg Andrographolide coming from a 40% Andrographis paniculata extract.)
  • LEO-HB® Technology has developed a 100% food grade vegan formula, patent-protected, made from Andrographis paniculata extract 40% Andrographolide in cyclodextrins and a specific starch which enhances the bioaccessibility and solubility of Andrographis LEO-HB® 
  • 1,000 mg yields 120 mg of Andrographolide with a minimum of 96 mg of fully Cold Water Soluble Andrographolide – unachievable by conventional extracts regardless of dose.
Andrographis LEO-HB® Solubility Chart


Andrographis paniculata, with its rich phytochemistry, historical uses in traditional medicine, and modern applications, has garnered attention for its potential health benefits. Human trials have provided valuable insights into its effectiveness in various health conditions, including upper respiratory tract infections, immune support, anti-inflammatory properties, digestive health, and antioxidant effects.

LEO-HB® Technology, with its solid-solid dispersion process, greatly  enhances the bioavailability and solubility of Andrographis at levels unachievable by conventional extracts. 

Human trials have demonstrated promising results, suggesting that Andrographis can be a valuable addition to the arsenal of natural remedies and may have a role in modern healthcare. More research is needed to further validate its efficacy, establish optimal dosages, and determine potential side effects. Nevertheless, the findings from human trials on Andrographis are encouraging and warrant continued exploration of this remarkable medicinal plant.

* Referenced Clinical trails can be found on our website  HERE 

**These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure or prevent any disease.