• Gastrointestinal conditions*
  • Blood sugar Management*
  • Mood*
  • Microbiota Modulation*
  • Weight Management*
  • Heart Health*
Berberine LEO-HB® Cold Water Dispersible Powder

A New Generation of Cold Water Dispersible Ingredients

Gut Health Icon
Blood sugar Management Icon
Weight Management icon
Mood Enhancer Icon
Heart Health Icon


  • yellow to light orange powder, instantly Cold Water Dispersible, derived from an alkaloid found in the barks, leaves, twigs, rhizomes, roots, and/or stems of various plants, such as the barberry, Oregon grape, and tree turmeric.
  •  Traditionally used as an antimicrobial, antiprotozoal, and antidiarrheal agent in Ayurvedic medicine and traditional Chinese medicine.
  • Taste: very bitter
  • Recommended Dosage: 375 mg to 750 mg daily

Cold Water Dispersible Powder Berberine LEO-HB®

Clean Label Ingredients

Active Ingredient:
Berberine HCl

Other Ingredients:
Vegan formula: fiber and glycerin
Non-Vegan formula: hydrolyzed collagen and glycerin

Emulsifier-Free Icon

LEO-HB® Technology

  • LEO-HB® is an eco-friendly, state-of-the-art solid-solid technology that turns poorly soluble, bioactive ingredients with low bioavailability into free-flowing high performance powders that are instantly Cold Water Dispersible and/or Soluble.
  • Contrary to many other technologies, LEO-HB® is a 100% natural, clean-label process, only uses non-GMO food-grade ingredients, NO solvents (NO P.E.G, NO Polysorbates) NO artificial emulsifiers, and has no negative impact on the digestive tract.
  • Only Food-Grade, Non-GMO Clean Label Ingredients are used for every LEO-HB® ingredient: natural carrier (vegan or non-vegan), selected bioactive extract, natural glycerin (NO artificial emulsifiers, NO excipients, NO solvents)
  • Final LEO-HB® ingredient powders:
    • Are Cold Water Dispersible (80% min. vs. 0% for the unprocessed raw material)
    • Offer maximum bioavailability from 3x to 20x+
    • Offer customizable particle size

Dispersibility Assay

Left: Berberine LEO-HB®

Right: Berberine HCL

Solubility:  Berberine LEO-HB® vs Native Berberine in acid medium


50 ml 0.1 N HCL solution

Ambient temperature

30-40mg of product

Berberine in Clinical Studies

Berberine is a natural plant compound that has been used for centuries in traditional medicine to treat a variety of health conditions. Today, it is gaining widespread attention for its potential to support overall health and well-being. Berberine has been extensively researched for its ability to lower blood sugar levels and improve insulin sensitivity, making it a powerful tool for managing diabetes and other blood sugar-related conditions. It has also been shown to have anti-inflammatory and antioxidant properties, which can help reduce the risk of chronic diseases and promote healthy aging. Additionally, berberine has antimicrobial effects, making it a useful supplement for supporting immune function and treating infections caused by bacteria, viruses, and fungi.

  1. Cardiovascular and Metabolic Properties
    • Action on AMPK/ insulin secretion
    • Microbiota modulation, digestive enzymes
  2. Neuroprotective Properties
    • Cholinesterase inhibitor (MAO…)
  3. Anti-Inflammatory Properties
    • Decrease in inflammatory markers (COX, PG…)
  4. Anti-Microbial Properties
    • inhibition of bacterial protein synthesis
  5. Anti-Tumor Properties
    • Inhibition of cellular proliferation
    • Apoptosis regulation

Design Your Next Cutting-Edge Product with LEO-HB®

Powered_by_LEO-HB® Logo