Skeletal Muscle Mass

Skeletal muscle mass refers to the total amount of muscle tissue in the body that is attached to the bones and is responsible for movement of the body. Skeletal muscle is the most abundant type of muscle tissue in the body. As we age, there is a natural decline in skeletal muscle mass, strength, and function, a phenomenon known as sarcopenia. This is due to a combination of factors, including reduced physical activity, hormonal changes, and changes in nutrient metabolism. The decline in muscle mass begins around the age of 30 and accelerates after the age of 60, with an estimated loss of 3-5% of muscle mass per decade. Sarcopenia can lead to a range of health problems, including impaired mobility, falls, frailty, and metabolic disorders.

A New Generation of Cold Water Dispersible and Soluble Ingredients

CoQ10 LEO-HB® icon

CoQ10 LEO-HB®

Urolithin LEO-HB® icon

Urolithin LEO-HB®

Ursolic Acid LEO-HB® icon

Ursolic Acid LEO-HB®

CoQ10 may help to increase skeletal muscle mass by improving energy production within muscle cells. CoQ10 is involved in the production of ATP, which is the primary source of energy for muscle contractions. By increasing ATP production, CoQ10 may enhance the ability of muscles to contract and generate force, leading to an increase in muscle mass. CoQ10 has also been shown to have antioxidant properties, which can protect muscles from damage caused by free radicals. By reducing oxidative stress in muscles, CoQ10 may help to prevent muscle damage and maintain muscle mass. CoQ10 has also been shown to improve exercise performance in some studies. It may help to reduce fatigue during exercise and improve recovery after exercise, which can lead to increased muscle growth over time.

Urolithin may help with skeletal muscle mass by activating a cellular pathway called mitophagy. Mitophagy is a process by which damaged mitochondria (the energy-producing organelles in cells) are removed and replaced with new ones. As we age, the efficiency of this process declines, leading to a buildup of damaged mitochondria and a decline in muscle mass and function. Urolithin has been shown to stimulate mitophagy in muscle cells, which may help to preserve muscle mass and function. Urolithin has also been found to stimulate the production of new muscle cells (a process called myogenesis) and to increase muscle protein synthesis. These effects are thought to be mediated through the activation of a signaling pathway called the AMPK/mTOR pathway.

One way that ursolic acid may help to increase skeletal muscle mass is by activating a protein called mTOR, which is involved in muscle protein synthesis. This can lead to an increase in muscle protein production and subsequent muscle growth. In addition to its effect on mTOR, Ursolic Acid has also been shown to reduce muscle atrophy (the loss of muscle tissue), which can occur as a result of aging, disease, or injury. Ursolic Acid has been found to increase the activity of enzymes that are involved in muscle protein breakdown, which can help to maintain or increase muscle mass. It has also been shown to increase the production of insulin-like growth factor-1 (IGF-1), a hormone that is involved in muscle growth and development.